46 COS

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The open access journal Tropical Medicine & Surgery publishes significant and influential scientific works in all fields of tropical medicine and surgery, including emerging infectious diseases, neglected tropical diseases, non-communicable diseases, tropical biomedicine, tropical diseases, tropical fish diseases, tropical fish medicine, tropical health nutrition, tropical medicine, tropical medicine and health, and tropical medicine and hygiene. Publications on parasitology, veterinary medicine, and epidemiology that are closely related to tropical medical research are also welcomed. The journal's scope goes beyond just tropical medicine. Because it will allow them to build on their current knowledge, it is a blessing for researchers and students who wish to keep current on the most recent discoveries in the medical field.

Life course studies are made for observational and, increasingly, interventional research. They are intended to "collect once, utilise several times." Core Outcome Sets (COS) are minimal sets created through multi-stakeholder consensus processes for clinical trials. In order to help early life cohorts with an interventional focus pick outcomes, we sought to aggregate published COS.

We looked for COS published before January 2021 that were pertinent to four life stages (pregnancy, new births, children under 8, and parents (adults 18–50 years)) in PubMed, Medline, COMET, and CROWN. We combined key findings into broad frameworks.

We converted 414 core outcomes from 46 COS into 118 components. All stages had the same definitions of "quality of life," "adverse occurrences," "medication use," "hospitalisation," and "mortality." During pregnancy, common constructs included "preterm birth," "delivery mode," "pre-eclampsia," "gestational weight gain," "gestational diabetes," and "haemorrhage: These constructs comprised "birthweight," "small for gestational age," "neurological damage," "morbidity," and "infection/sepsis" for newborns; "pain," "gastrointestinal morbidity," "growth/weight," and "haemorrhage" for children;

The outcome structures that were produced by this COS synthesis are very valuable to stakeholders (participants, healthcare professionals, and services), pertinent to life course research, and may be able to position cohorts for trial capacity.